Grima, Anankos, Velezark, and Nemesis all lie dead. Yet the worlds are experiencing strange anomalies. A resurrected Sothis appears, proclaiming a radical truth that shocks everyone. Shadowy but familiar enemies lurk in the darkness, longing for blood. Will the heroes be able to save the worlds and help guide an era where the worlds and religion are fusing together, or chaos rule?

Sara Trantoul's soul appears to Julius and reveals that it is time for her to move onward to Heaven. However, if Sara's soul leaves the Vampire Killer, it will weaken immensely. There is only one way to ensure the whip's strength: the team must find the Sanctifying Stone. But when old adversaries attack, will they be able to succeed, or will Sara be trapped in the whip forever?

After Hades was defeated, Pit has led a quiet life. That is, until Palutena announced a permanent merge of forces between Palutena's Army and the Forces of Nature. The process begins by exchanging lavish gifts to the other goddess. However, Phosphora has a special present for Pit, but before she is able to give it to him, is captured by Hades. Can Pit save his not-so-secret crush?