Holmes and Watson were young men and beginning their partnership when they were confronted with a mystery that would have a profound effect on the great detective's future. Holmes had forbidden Watson to ever write of Anne but forty years after the events chronicled in this story he finally agreed. 'Holmes and Anne' was the last Sherlock Holmes story that Watson would ever write.

During his first week in Meryton Darcy is responsible for an accident that seriously injures Kitty Bennet and they are forced to marry. With the passage of time, and a good deal of patience and forgiveness, their relationship evolves in a manner that is as unexpected as it is gratifying.